But in 2000, Cartoon Network premiered stealth pilots for the show's spin-offs The Brak Show, Sealab 2021, Harvey Birdman, Attorney at Law, and Aqua Teen Hunger Force.On September 2, 2001, new episodes of the series, along with re-runs of the existing episodes, moved to Adult Swim, a late night programming block, launched by Cartoon Network that night.

Two final seasons were released on Game Tap from 2006 to 2008.

There were a total of 110 episodes, over the course of 11 seasons.

In the special, Space Ghost interviewed a few of the new directors, while the Council of Doom were the judges of the cartoon clips.

The first run ended on December 17, 1999, ending with the episode "King Dead".

Space Ghost Coast to Coast is an American adult animated parody talk show, created by Mike Lazzo and hosted by the 1960s Hanna-Barbera cartoon character Space Ghost.

Though the original 1960s series aired as a standard Hanna-Barbera Saturday-morning superhero cartoon, Space Ghost Coast to Coast was a total reboot of the series intended for adults, now reinterpreted as a surreal spoof talk show and produced using the original artwork.

The series ended its television run in 2004 with "Live at the Fillmore".

In 2006, the series returned as a five-minute web series on Turner Broadcasting's Game Tap online pay service in which Space Ghost interviewed celebrities from the video game industry and Game Tap's artist of the month.

They frequently disrupted the show and made no secret of the fact that they hated him.