The need for continued treatment should be reassessed periodically.If signs and symptoms of tardive dyskinesia appear in a patient on antipsychotics, drug discontinuation should be considered.

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Navane is effective in the management of schizophrenia.

Navane has not been evaluated in the management of behavioral complications in patients with mental retardation.

However, some patients may require treatment despite the presence of the syndrome.

(For further information about the description of tardive dyskinesia and its clinical detection, please refer to "Information for Patients" in the PRECAUTIONS section, and to the ADVERSE REACTIONS section.) A potentially fatal symptom complex sometimes referred to as Neuroleptic Malignant Syndrome (NMS) has been reported in association with antipsychotic drugs, including thiothixene.

Navane is not approved for the treatment of patients with dementia-related psychosis ( The thioxanthenes differ from the phenothiazines by the replacement of nitrogen in the central ring with a carbon-linked side chain fixed in space in a rigid structural configuration.

An N, N-dimethyl sulfonamide functional group is bonded to the thioxanthene nucleus.The effect that symptomatic suppression has upon the long-term course of the syndrome is unknown.Given these considerations, antipsychotics should be prescribed in a manner that is most likely to minimize the occurrence of tardive dyskinesia.Clinical manifestations of NMS are hyperpyrexia, muscle rigidity, altered mental status and evidence of autonomic instability (irregular pulse or blood pressure, tachycardia, diaphoresis, and cardiac dysrhythmias).The diagnostic evaluation of patients with this syndrome is complicated.Both the risk of developing the syndrome and the likelihood that it will become irreversible are believed to increase as the duration of treatment and the total cumulative dose of antipsychotic drugs administered to the patient increase.